eSwasthya uses a microfranchise model to deliver the services of a doctor to the doorsteps of rural populations. Female health workers rigorously trained in healthcare, technology and business invest in setting up a clinic from their homes. When patients visit with a complaint, the health worker uses mobile phone technology to connect to centrally-located paramedics and doctors who triage the call, identify illnesses and recommend treatment. Patients pay a nominal fee. eSwasthya has 51 centers and has treated 45,000 patients across three districts in Rajasthan.

Piramal Healthcare Ltd. launched eSwasthya in 2008. The program was integrated into HMRI services in 2011.